1. Signaling Pathways
  2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR

Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-103456R
    PHTPP (Standard)
    Antagonist
    PHTPP (Standard) is the analytical standard of PHTPP. This product is intended for research and analytical applications. PHTPP is a selective estrogen receptor β (ERβ) antagonist with 36-fold selectivity over ERα.
    PHTPP (Standard)
  • HY-13757R
    Tamoxifen Citrate (Standard)
    Modulator
    Tamoxifen (Citrate) (Standard) is the analytical standard of Tamoxifen (Citrate). This product is intended for research and analytical applications. Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.
    Tamoxifen Citrate (Standard)
  • HY-W338581
    4-tert-Octylphenol monoethoxylate
    4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent.
    4-tert-Octylphenol monoethoxylate
  • HY-12452R
    DPN (Standard)
    Agonist
    DPN (Standard) is the analytical standard of DPN. This product is intended for research and analytical applications. DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases.
    DPN (Standard)
  • HY-B1100R
    Estradiol cypionate (Standard)
    Inhibitor
    Estradiol cypionate (Standard) is the analytical standard of Estradiol cypionate. This product is intended for research and analytical applications. Estradiol cypionate is the 17β-cypionate ester of Estradiol, which inhibits ET-1 synthesis by acting on estrogen receptors.
    Estradiol cypionate (Standard)
  • HY-169941
    ERα/ERβ antagonist-1
    Antagonist
    ERα/ERβ antagonist-1 (Compound 10) is partial antagonists of ERα and ERβ. ERα/ERβ antagonist-1 reduces ERα and ERβ activity in a dose-dependent manner in HepG2 liver cells.
    ERα/ERβ antagonist-1
  • HY-N1875
    4-(Ethoxymethyl)phenol
    Agonist 98.02%
    4-(Ethoxymethyl)phenol (p-Hydroxybenzyl Et ether) is a potent antioxidant from Amburana cearensis leaf extract, with in vitro cytogenotoxic properties. Amburana cearensis leaves can be used foe the research of respiratory diseases and inflammations.
    4-(Ethoxymethyl)phenol
  • HY-N13076
    Neo-sagittasine A
    Neo-sagittasine A (compound 2) is an estrogen biosynthesis promoter that can enhance estrogen biosynthesis in human ovarian granulosa-like KGN cells. Neo-sagittasine A can be isolated from Epimedium brevifolium.
    Neo-sagittasine A
  • HY-W011100R
    Cyclofenil (Standard)
    Modulator
    Cyclofenil (Standard) is the analytical standard of Cyclofenil. This product is intended for research and analytical applications. Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity.
    Cyclofenil (Standard)
  • HY-138089
    17β-Hydroxy exemestane
    Agonist
    17β-Hydroxy exemestane (17-H-EXE) is the primary active metabolite of Exemestane (HY-13632). 17β-Hydroxy exemestane is an aromatase inhibitor (IC50 = 69 nM) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). 17β-Hydroxy exemestane stimulates growth of AR- and ERα-positive MCF-7 (EC50= 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7 cells. 17β-Hydroxy exemestane inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae in ovariectomized rats.
    17β-Hydroxy exemestane
  • HY-N13290
    10-Chloroestra-1,4-diene-3,17-dione
    Control
    10-Chloroestra-1,4-diene-3,17-dione (10-CIEsra) is a derivative of estrogen receptor.
    10-Chloroestra-1,4-diene-3,17-dione
  • HY-B0845R
    Prochloraz (Standard)
    Antagonist
    Prochloraz (Standard) is the analytical standard of Prochloraz. This product is intended for research and analytical applications. Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.
    Prochloraz (Standard)
  • HY-121441
    Fispemifene
    Modulator
    Fispemifene, an orally active selective estrogen receptor modulator with anti-inflammatory and antiestrogenic action, attenuates glandular inflammation in an animal model of chronic nonbacterial prostatitis.
    Fispemifene
  • HY-100583R
    (-)-(S)-Equol (Standard)
    (-)-(S)-Equol (Standard) is the analytical standard of (-)-(S)-Equol. This product is intended for research and analytical applications. (-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.
    (-)-(S)-Equol (Standard)
  • HY-151230
    (-)-Erteberel
    Agonist
    (-)-Erteberel is a selective estrogen receptor beta (ERβ) agonist. (-)-Erteberel can be utilized in the study of diseases mediated by estrogen receptor beta (ERβ), such as prostate cancer.
    (-)-Erteberel
  • HY-W150752
    Triphenylethylene
    Antagonist 99.86%
    Triphenylethylene is an aromatic hydrocarbon that possesses weak estrogenic activity. Triphenylethylene antiestrogens relax duodenal intestinal muscle via a mechanism that involves inhibition of L-type Ca2+ channels but not activation of K+ channels.
    Triphenylethylene
  • HY-108414R
    (R)-Equol (Standard)
    Agonist
    (R)-Equol (Standard) is the analytical standard of (R)-Equol. This product is intended for research and analytical applications. (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively.
    (R)-Equol (Standard)
  • HY-B1176S1
    Equilin-d2
    Agonist
    Equilin-d2 (7-Dehydroestrone-d2) is deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism.
    Equilin-d<sub>2</sub>
  • HY-B1361R
    Estropipate (Standard)
    Agonist
    Estropipate (Standard) is the analytical standard of Estropipate. This product is intended for research and analytical applications.
    Estropipate (Standard)
  • HY-13738R
    Raloxifene (Standard)
    Modulator
    Raloxifene (Standard) is the analytical standard of Raloxifene. This product is intended for research and analytical applications. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research.
    Raloxifene (Standard)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity

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